In Vitro Metabolism
We offer comprehensive preclinical pharmacokinetic (PK) study services, covering a wide range of test article types, including small molecule drugs, biotechnology drugs (e.g., monoclonal antibodies, recombinant proteins, oligonucleotides, etc.), and natural product drugs. Our services encompass experimental design, sample analysis, data interpretation, and report writing, covering the determination of key parameters such as absorption, distribution, metabolism, and excretion (ADME). With extensive experience and advanced analytical platforms, we are committed to providing our clients with high-quality data and professional technical support to accelerate your drug development process.
Main Services:
1. Drug Metabolism Studies:
Comprehensive drug metabolism study services covering liver microsomal/hepatocyte metabolism, plasma stability, metabolite identification/confirmation, metabolic phenotyping, and in vitro and in vivo metabolite identification and metabolic pathway analysis. This mainly includes:
Liver Microsome Metabolism Assay
Hepatocyte Metabolic Stability Assay
Plasma Stability Assay
Drug Metabolite Identification and Confirmation
Metabolic Phenotyping
In Vitro System (hepatocytes, S9 fraction, liver microsomes, etc.) Metabolite Identification and Metabolic Pathway Analysis/Prediction
In Vivo System (plasma, urine, bile, feces, etc.) Metabolite Identification and Determination of Metabolic Pathways
2. Drug-Drug Interaction Studies:
CYP450 Inhibition Assay
CYP450 Induction Assay
3. Drug Distribution Studies:
Plasma Protein Binding Assay
Caco-2 Transcellular Transport Assay
4. Software Applications:
We utilize professional pharmacokinetic analysis software, WinNonlin and Analyst, for data calculation, processing, and analysis, thereby supporting the laboratory's scientific management.
