In Vitro Enzymatic Screening (Kinase Assays)

We offer precise and efficient in vitro kinase activity testing services, employing industry-leading technology platforms such as ADP-Glo, HTRF, and NanoBRET to achieve high-sensitivity, high-throughput detection. Our services cover a broad range of kinase families, including AGC, CAMK, CK1, CMGC, STE, TK, TKL, and atypical protein kinases, providing reliable, high-quality data for drug development, target validation, and mechanism of action studies, and helping you achieve scientific breakthroughs.

FDA批准的人类激酶组激酶抑制剂

We offer a wide range of kinase testing services, covering key kinase families and pathways within the cell signaling network. Currently, our testing targets include:

1. AGC Kinase Family:

This family includes many key kinases involved in cell growth, proliferation, survival, and metabolism, such as protein kinase A (PKA), protein kinase B (Akt), and protein kinase C (PKC). Our testing services can help researchers gain insight into the roles of these kinases in various cellular processes.

2. CMGC Kinase Family:

This family includes kinases involved in cell cycle regulation, transcriptional regulation, and other important cellular processes, such as cyclin-dependent kinase (CDK) family members and members of the MAPK family (such as ERK, JNK, and p38). By testing these kinases, we can help researchers elucidate the regulatory mechanisms of key biological processes such as the cell cycle, cell growth, and stress responses.

3. TK (Tyrosine Kinase Family):

Tyrosine kinase family members are widely involved in various key cellular processes such as cell growth, differentiation, proliferation, and apoptosis, and are closely related to the occurrence and development of various diseases. We provide testing services for a variety of receptor tyrosine kinases (RTKs), non-receptor tyrosine kinases (nRTKs), and other tyrosine kinases, such as epidermal growth factor receptor (EGFR), vascular endothelial growth factor receptor (VEGFR), etc., providing important technical support for cancer research, immunology research, and more.

4. Other Kinases:

In addition to the main kinase families mentioned above, we also provide testing services for other important kinases, such as AMPK (involved in energy metabolism) and ATM/ATR (involved in DNA damage repair), to meet a broader range of research needs.

Based on these targets, our services can provide your research with in-depth insights into cell cycle, growth and proliferation, apoptosis, DNA damage response, immune regulation, metabolic regulation, and other important cellular processes. We are committed to providing high-quality testing data, comprehensive experimental reports, and professional technical interpretation to support your research efforts.

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Kinase Target Overview

2. ADP-Glo Assay to Detect EGFR (L858R/T790M) Kinase Inhibitory Activity

                             
 

 3. HTRF Assay to Detect JAK1 Kinase Inhibitory Activity

                         
 

4. NanoBRET Assay to Detect Inhibition of TYK2-JH2 Binding