In vitro Receptor Biology
We offer G protein-coupled receptor (GPCR) activity testing services based on advanced technologies such as time-resolved fluorescence resonance energy transfer (TR-FRET), AlphaScreen, and homogeneous time-resolved fluorescence (HTRF). We can detect a variety of GPCR pathways, including Gs, Gi, and Gq, and provide screening and activity evaluation of corresponding agonists, antagonists, and allosteric modulators. For example, we use TR-FRET technology to detect the agonist activity of morphine on cellular μ-opioid receptors, and evaluate its potency by measuring intracellular cAMP levels. Our experienced team can customize experimental protocols according to your specific research needs, providing one-stop service from experimental design and data collection to results analysis, and provide high-quality data and detailed experimental reports, providing strong support for your GPCR drug development.
1. TR-FRET Assay to Detect Agonist Activity of Morphine on Cellular Opioid-μ Receptor (Measuring cAMP Levels):
2. AlphaScreen Assay to Detect Inhibitory Activity of Compounds on Cellular Cholinergic Receptor M3 (Measuring Intracellular Ca2+):
3. GPCR Targets
